Aspectos clínicoepidemiológicos de pacientes con cáncer de mama del Policlínico 28 de septiembre / Clinical-Epidemiological Aspects of Patients with Breast Cancer and from the Policlínico 28 de Septiembre of Santiago de Cuba

Introducción: El cáncer de mama es considerado como un serio problema de salud pública por la alta prevalencia tanto en países desarrollados como en desarrollo. Son escasos los estudios clínico-epidemiológicos actualizados en el área de salud del Policlínico 28 de septiembre relacionados con dicha entidad clínica. Objetivo: Caracterizar desde el punto de vista clínico y epidemiológico a pacientes con cáncer de mama del área de salud perteneciente al Policlínico 28 de septiembre. Métodos: Estudio descriptivo en una serie de 35 mujeres mayores de 30 años con diagnóstico confirmado de cáncer de mama. Las variables estudiadas comprendieron edad, antecedentes familiares de cáncer de mama, factores de riesgo generales y hormonales, signos y síntomas clínicos, resultados de estudio ecográfico y diagnóstico histopatológico. Se utilizó el porcentaje como medida de resumen. Resultados: El 42,8 por ciento de la muestra objeto de estudio estuvo comprendido en el grupo de edad de 40-49 años. El 65,7 por ciento del total de mujeres tenía antecedentes familiares de cáncer de mama. La menarquía precoz (54,2 por ciento) y la nuliparidad (48,5 por ciento) representaron los factores de riesgo de mayor incidencia. El 57,1 por ciento de las lesiones diagnosticadas correspondieron a carcinomas en estadío I y IIa. Conclusiones: El cáncer de mama constituye un serio problema de salud en mujeres mayores de 30 años pertenecientes al Policlínico 28 de septiembre del municipio Santiago de Cuba(AU)

Introduction: Breast cancer is considered a serious public health concern due to its high prevalence in both developed and developing countries. There are few updated clinical-epidemiological studies carried out in the health area of the Policlínico Docente 28 de Septiembre related to this clinical entity. Objective: To characterize, from the clinical and epidemiological point of view, the patients with breast cancer and from the health area belonging to the Policlínico Docente 28 de Septiembre. Methods: A descriptive study was carried out with a series of 35 women aged more than 30 years and with a confirmed diagnosis of breast cancer. The variables studied included age, family history of breast cancer, general and hormonal risk factors, clinical signs and symptoms, ultrasound findings and histopathological diagnosis. Percentage was used as summary measure. Results: 42.8 percent of the study sample was in the age group 40-49 years old. Of the total number of women, 65.7 percent had a family history of breast cancer. Early menarche (54.2 percent) and nulliparity (48.5 percent) represented the risk factors with the highest incidence. 57.1 percent of the diagnosed lesions corresponded to stage I and IIA carcinomas. Conclusions: Breast cancer is a serious health problem in women older than 30 years and belonging to the Policlínico Docente 28 de Septiembre, of Santiago de Cuba Municipality(AU)

Pubertad en pacientes con hiperplasia adrenal congénita por déficit de 21hidroxilasa y asignación femenina / Puberty in patients with congenital adrenal hyperplasia due to a 21-hydroxylase deficit and female assignment

RESUMEN Introducción: En la hiperplasia adrenal congénita el aumento de los niveles de andrógenos suprarrenales en las pacientes no tratadas o mal controladas, puede alterar el inicio y/o la progresión puberal (progresión puberal/progresiones puberales?). Objetivos: Describir las características puberales de pacientes con hiperplasia adrenal congénita asignadas como femeninas e identificar si existe asociación entre elementos relacionados con la enfermedad y el inicio y progresión puberales. Métodos: Se incluyeron todas las pacientes con diagnóstico de hiperplasia adrenal congénita asignadas como femeninas, que fueron atendidas en el INEN de enero 2000 a mayo 2019. Resultados: Fueron estudiadas 47 pacientes, con una media de edad de 14,76 ± 7,04 años. Se comprobó un predominio de las formas clínicas clásicas en 25 pacientes (53,19 por ciento), de ellas 11 (23,40 por ciento) fueron formas virilizantes simples, 14 (29,78 por ciento) perdedoras de sal y 22 (46,80 por ciento) formas no clásicas. El inicio del vello pubiano fue a una edad promedio de 7,78 ± 3,2 años. El comienzo de la telarquia resultó en una media de 10,09 ± 2,4 años y la menarquia a los 12,2 ± 2,3 años como promedio. De las 29 pacientes que ya habían menstruado 16 (55,2 por ciento) presentaban irregularidades menstruales. El tiempo entre el inicio puberal y la menarquia fue de 3,4 años en las formas no clásicas, 5,6 años en las perdedoras de sal y 7,0 años en las virilizantes simples. La edad al diagnóstico, la edad de inicio del tratamiento y la dosis de esteroides empleada se relacionaron con algunos aspectos puberales. Conclusiones: El diagnóstico oportuno y el ajuste cuidadoso del esquema esteroideo, constituyen pilares importantes en el inicio y progresión puberales, y en la consecución de ciclos ovulatorios regulares que aseguren desde la adolescencia, un inicio y desarrollo puberales normales y en edades reproductivas, la optimización de la fertilidad(AU)

ABSTRACT Introduction: In the congenital adrenal hyperplasia, the increased levels of adrenal androgens in patients untreated or poorly controlled can alter the start and/or pubertal progression (pubertal progression/pubertal progressions). Objectives: To describe the pubertal characteristics of patients with congenital adrenal hyperplasia assigned as females and to identify whether there is an association between elements related to the disease and the pubertal onset and progression. Methods: There were included all patients diagnosed with congenital adrenal hyperplasia assigned as females that were attended at the National Institute of Endocrinology from January 2000 to May 2019. Results: 47 patients were studied, with an average age of 14.76 ± 7.04 years. It was found a predominance of classic clinical forms in 25 patients (53.19 percent, of which 11 (23.40 percent) had simple virilization forms, 14 (29.78 percent) were salt-losers and 22 (46.80 percent) had non-classical forms. The onset of the pubic hair was at an average age of 7.78 ± 3.2 years. The beginning of the thelarche resulted in an average of 10.09 ± 2.4 years and menarche at the 12.2 ± 2.3 years on average. Of the 29 patients who had menstruated, 16 (55.2 percent) presented menstrual irregularities. The time between the puberty onset and menarche was 3.4 years in the non-classical forms, 5.6 years in the salt-losers, and 7.0 years in the simple virilizations. The age at initial diagnosis treatment and the dose of steroids used were related to some pubertal aspects. Conclusions: Early diagnosis and careful adjustment of the steroid scheme are important pillars in the pubertal onset and progression, the achievement of regular ovulatory cycles, and with it, in the optimization of fertility(AU)

Aspectos reprodutivos de mulheres celíacas no Brasil / Reproductive aspects in brazilian celiac women

ABSTRACT BACKGROUND: Celiac disease (CD) is a chronic enteropathy in response to ingestion of gluten. CD was associated with gynecological disorders. OBJECTIVE: In this retrospective study, we aimed to investigate the age of menarche, age of menopause, number of pregnancies and abortions in Brazilian celiac patients. METHODS: We studied 214 women diagnosed with CD and as control group 286 women were investigated. RESULTS: Regarding the mean age of menarche, a significant difference was found (12.6±1.40 in CD and 12.8±1.22 years in healthy group; P=0.04). Regarding abortions, in CD women 38/214 (17.8%) and 28/286 (9.8%) in the control group reported abortion (P=0.0092, OR:1.98; CI95%=1.1- 3.3). There was no significant difference in the mean age of menopause nor number of pregnancies per woman. CONCLUSION: In this study, we found that celiac women had a higher mean age of menarche and higher risk of spontaneous abortions.

RESUMO CONTEXTO: A doença celíaca é uma enteropatia crônica em resposta à ingestão de glúten e já foi associada a distúrbios ginecológicos. OBJETIVO: Neste estudo retrospectivo, visamos investigar a idade da menarca, idade da menopausa, número de gestações e abortos em pacientes celíacas brasileiras. MÉTODOS: Foram estudadas 214 mulheres com diagnóstico de doença celíaca e no grupo controle, 286 mulheres foram investigadas. RESULTADOS: Em relação à média de idade da menarca foi encontrada diferença significativa (12,6±1,40 na doença celíaca e 12,8±1,22 anos no grupo controle; P=0,04). Em relação aos abortos, nas mulheres com doença celíaca 38/214 (17,8%) relataram ter tido pelo menos um abortamento espontâneo, enquanto que 28/286 (9,8%) no grupo controle relataram aborto (P=0,0092, OR: 1,98; IC95% = 1,1-3,3). Não houve diferença significativa na idade média da menopausa nem no número de gestações por mulher. CONCLUSÃO: Neste estudo, constatamos que as mulheres celíacas apresentaram maior idade média de menarca e maior risco de abortos espontâneos.

Estudo comparativo da potência aeróbica entre os estágios maturacionais determinados pela menarca / Comparative study of aerobio power between maturational stages determined by menarche / Estudio comparativo de la potencia aeróbica entre las etapas de maduración determinadas por la menarquia

RESUMO Objetivo Identificar e comparar a potência aeróbica entre os estágios maturacionais determinados pela menarca. Métodos Participaram 19 alunas de 10 a 14 anos do ensino fundamental de um colégio particular da cidade Itajubá-MG, praticantes de atividades físicas escolares; seis do estágio M0, sete do estágio M e seis do estágio M1. O estudo empregou uma tipologia quase experimental e delineamento comparativo. Estatisticamente, utilizou-se Anova One-Way para comparar as variáveis entre os estágios de maturação, seguida de post-hoc de Tukey. O nível de significância foi p<0,05. Resultados Descritivamente, a potência aeróbia foi identificado nos três estágios maturacionais, sendo absolutamente: M0 1,7 ± 0,32, para M 2,2 ± 0,26 e para M1 2,6 ± 0,43 L/min e relativamente: M0 41,4 ± 1,72, para M 46,5 ± 4,51, e para M1 43,9 ± 5,42 ml/kg.min. Observou-se diferença significativa com p=0,001 no VO2 máximo absoluto, tendo um aumento progressivo do VO2 máximo absoluto juntamente com a maturação sexual, não havendo diferença significativa do VO2 máximo relativo com p=0,125. Discussão e Conclusão Conclui-se que existe um aumento significativo do VO2 máximo absoluto juntamente com o avanço maturacional, e no VO2 máximo relativo, não identificamos diferenças significativas entre os estágios maturacionais determinados pela menarca com declínio após um ano da ocorrência da menarca.(AU)

ABSTRACT Objective To identify and compare the aerobic power between the maturation stages determined by menarche. Methods Participated 19 students from 10 to 14 years of the primary school of a private school in the city of Itajubá-MG, practicing physical school activities; six from stage M0, seven from stage M and six from stage M1. The study used a quasi-experimental typology and a comparative design. Statistically, Anova One-Way was used to compare variables between maturation stages, followed by Tukey's post-hoc. The level of significance was p<0.05. Results Descriptively, the aerobic power was identified in the three stages of maturation, being absolutely: M0 1.7 ± 0.32, for M 2.2 ± 0.26 and for M1 2.6 ± 0.43 L/min and relatively: M0 41.4 ± 1.72, for M 46.5 ± 4.51 and for M1 43.9 ± 5.42 ml/kg.min. There was a significant difference with p = 0.001 in the absolute maximum VO2, with a progressive increase in the absolute maximum VO2 along with sexual maturation, without significant difference in the relative maximum VO2 with p = 0.125. Discussion the conclusion We conclude that there is a significant increase in the absolute maximum VO2 together with the progression of maturation, and in the relative maximum VO2, we did not identify significant differences between the maturation stages determined by menarche with a decrease after one year of occurrence of menarche.(AU)

RESUMEN Objetivo Identificar y comparar la potencia aeróbica entre las etapas de maduración determinadas por la menarquia. Métodos Participaron 19 estudiantes de 10 a 14 años de la escuela primaria de un colegio privado de la ciudad de Itajubá-MG que practican actividades escolares físicas; seis de la etapa M0, siete de la etapa M y seis de la etapa M1. El estudio empleó una tipología cuasiexperimental y un diseño comparativo. Estadísticamente, se utilizó Anova One-Way para comparar las variables entre las etapas de maduración, seguido del post hoc de Tukey. El nivel de significancia fue p<0.05. Resultados Descriptivamente, se identificó la potencia aeróbica en las tres etapas de maduración, siendo absolutamente: M0 1.7 ± 0.32, para M 2.2 ± 0.26 y para M1 2.6 ± 0.43 L / min y relativamente: M0 41,4 ± 1,72, para M 46,5 ± 4,51 y para M1 43,9 ± 5,42 ml / kg. min. Hubo una diferencia significativa con p = 0.001 en el VO2 máximo absoluto, con un aumento progresivo del VO2 máximo absoluto junto con la maduración sexual, sin diferencia significativa en el VO2 máximo relativo con p=0.125. Discusión Se concluyó que existe un aumento significativo en el VO2 máximo absoluto junto con la progresión de la maduración. En el VO2 máximo relativo no se identificaron diferencias significativas entre las etapas de maduración determinadas por la menarquia con un descenso después de un año de ocurrencia de la menarca.(AU)

The influence of maturational and morphological status pre- and post-menarche on the 100-m freestyle swimming performance of competitive teenagers

Abstract Aim: This study investigated whether the difference anthropometric of swimmers pre- and post-menarche influence the motor performance of a 100-m freestyle swimming test. Methods: Twenty-five female swimmers participated in this study, nine swimmers have not had menarche (age 11.7 ± 0.63), and sixteen swimmers already have had it (age 15.17 ± 1.36). Body composition (skinfold thickness), anthropometrical parameters (height and weight), and biological age (Tanner self-assessment) were measured. A univariate and multivariate linear regression analysis was run to assess which personal or anthropometric variable predicts the motor performance (time trial) on a 100-m freestyle swimming test in pre- and post-menarche participants. As well, it was performed a Pearson's correlation test between the maturational status on Tanner self-assessment and the motor performance. Results: Post-menarche swimmers demonstrated better motor performance than pre-menarche swimmers. Anthropometric characteristics did not predict the motor performance of pre-menarche swimmers. Age, height, and weight predicted 47.8% of the motor performance of post-menarche swimmers. The Tanner classification demonstrated a strong negative correlation with swimming performance. Conclusion: Anthropometric characteristics only impacted the motor performance of post-menarche swimmers.

ERICA: age at menarche and its association with nutritional status / ERICA: idade da menarca e sua associação com o estado nutricional

Abstract Objective: To estimate the mean age at menarche and its association with nutritional status in Brazilian adolescents. Methods: The study sample included female adolescents aged 12-17 who participated in a multicenter, school-based, country-wide, cross-sectional study entitled The Study of Cardiovascular Risk in Adolescents (Estudo de Riscos Cardiovasculares em Adolescentes [ERICA]). Mean and median ages at menarche in Brazil were estimated. The association of age at menarche with sociodemographic data and nutritional status were described as means and their respective 95% confidence intervals. Survival analysis was used to assess the age at menarche according to nutritional status categories and the log-rank test was used to compare the medians. Bivariate and multivariate analyses were performed using Cox regression to verify the association between menarche and other variables. Results: A total of 73,624 students were evaluated, comprising 40,803 girls, of whom 37,390 reported menarche at a mean age of 11.71 years and a median of 12.41 years. Median age at menarche was lower in overweight and obese girls (p < 0.001). The multivariate analysis showed that excess weight (HR = 1.28; 95% CI 1.21-1.36; p < 0.001) and studying in a private school (HR = 1.06; 95% CI 1.02-1.10; p = 0.003) were associated with menarche. Conclusions: This is a pioneering study in Brazil with national and regional representativeness to estimate the mean and the median age of occurrence of menarche. Adolescents with excess weight had an earlier menarche than their peers, even after adjustment for confounding factors.

Resumo Objetivo: Estimar a média de idade de ocorrência da menarca e sua associação com o estado nutricional em adolescentes brasileiras. Métodos: Foram avaliados dados de meninas com 12 a 17 anos a partir de um estudo seccional de base escolar, com representatividade nacional e macrorregional, o ERICA (Estudo de Riscos Cardiovasculares em Adolescentes). Foram estimadas média e mediana de idade de ocorrência da menarca no Brasil, pelo método recordatório. A associação da idade da menarca com dados sociodemográficos e estado nutricional foi descrita como médias e seus respectivos IC95%. Análise de sobrevida foi utilizada para explorar a idade da menarca segundo categorias de estado nutricional e teste logrank foi utilizado para comparação das medianas. Análises bivariada e multivariada foram realizadas por meio da regressão de Cox para verificar a associação entre menarca e demais variáveis. Resultados: Foram avaliados 73.624 estudantes, 40.803 meninas, das quais 37.390 referiram ter apresentado menarca, sendo a média da idade de ocorrência de 11,71 anos e a mediana de 12,41 anos. As medianas da idade de ocorrência da menarca foram menores naquelas com sobrepeso e obesidade (p < 0,001). A análise multivariada evidenciou que excesso de peso (HR = 1,28, IC95% 1,21-1,36, p < 0,001) e estudar em escola privada (HR = 1,06, IC95% 1,02-1,10, p = 0,003) estão associados à menarca. Conclusões: Este foi o primeiro estudo brasileiro com representatividade nacional a estimar a média de idade de ocorrência da menarca. As adolescentes com excesso de peso apresentaram menarca em idade inferior às demais, mesmo após ajuste.Full English text available from: www.revespcardiol.org/en

El adelanto en la telarquia y edad de la menarquia se relacióna con la malnutrición por exceso en niñas chilenas pero no en varones: estudio de base poblacional / The advance in thelarche and age of menarche is related to malnutrition by excess in Chilean girls but not in boys: population-based study

Introduction: Puberty normally begins after 8 years in girls and 9 years in boys. Objective: To determine the prevalence of signs of precocious puberty (PP), breast development in girls, premature gonadal development (PGD), premature adrenarche (PA), menarche age (MA) and its association with nutritional status (NS). Material and Methods: From a sample of 3.010 children from 5 to 14 years randomly selected in Santiago of Chile were chosen a subsample of 873 kids according to the cutoff to define PP. Survey was applied to obtain MA. Logistic regression were used to evaluate the relationship between PP and NS. Results: In boys the prevalence of PGD and PP was 8.55% and 3.16% respectively, no relationship was found with nutritional status In girls the prevalence of breast development and PA was 8.13% and 0.9% respectively. Only there be association between PP and NS in women: with a prevalence of 1,2%, 13,9% and 21,1% in well-nourished, Overweight and obesity are at greater risk of showing PP compared with eutrophic girls with an OR of 25,5 (IC 95% 3,2-203,0) and 46.93 (IC 95% 6,1-361,5). MA was 12,01 ± 0,94 years in eutrophic girls and 11,40 ± 0,96years in obese girls (p< 0,05). Conclusion: There was a positive correlation in females between overweight and obesity an PP and MA. There is a secular trend in MA, to compare these findings with other national studies. Obesity could have an important role in explaining the advancement observed in pubertal development.

Introducción: El desarrollo puberal se inicia normalmente después de los 8 años en niñas y de los 9 años en varones. Objetivo: Estimar la prevalencia de signos de pubertad precoz (sPP): crecimiento genital (CG) en varones, telarquia en niñas y vello púbico (VP) en ambos sexos; y determinar edad de la menarquia (EM) en una muestra de escolares de Santiago de Chile), y evaluar la asociación de estas variables con el estado nutricional (EN). Material y Métodos: Se examinaron 3.010 escolares de clase media baja de 6 a 14 años, pertenecientes a 10 colegios de Santiago de Chile y seleccionados aleatoriamente. En todos ellos se consignó peso, talla, IMC y desarrollo puberal según Tanner. Se aplicó una encuesta a los padres para obtener la EM a la población total de mujeres (n= 1.433). Para determinar sPP se analizaron por separado los 867 niños (62% mujeres) menores a la edad establecida como puntos de corte para definir PP. Se utilizó regresión logística para determinar la asociación existente entre sPP y el EN. Resultados: En varones la prevalencia de CG y VP fue de 8,55% y 3,16% y no se asocio al EN. La prevalencia de telarquia y VP en niñas fue de 8,13% y 0,9% respectivamente. Se observó una fuerte asociación entre telarquia y EN con prevalencias de 1.2%, 13.9% y 21.1% en eutróficas, sobrepeso y obesas, respectivamente (p< 0,0001) (Gráfico 1). La presencia de sobrepeso y/o obesidad otorgan un mayor riesgo de presentar telarquia, vs comparación con las niñas eutróficas con un OR de 25,5 (IC 95% 3,2-203,0) y 46.93 (IC 95% 6,1-361,5), respectivamente. La EM fue 12,01 ± 0,94 años en niñas eutróficas siendo de 11,40 ± 0,96 años en niñas obesas (p< 0,05). Conclusión: Se observó una correlación positiva solo en el sexo femenino entre malnutrición por exceso, telarquia precoz y EM. Se observa una tendencia secular en la EM al comparar los hallazgos con otros estudios nacionales.

Applicability of a novel mathematical model for the prediction of adult height and age at menarche in girls with idiopathic central precocious puberty

OBJECTIVES: Unfavorable predicted adult height and psychosocial inadequacy represent parameters used to guide therapeutic intervention in girls with central precocious puberty. Gonadotropin-releasing hormone analog is the first-line treatment. The aim of this study was to compare two methods used to predict adult height and assess a validated tool for predicting the age at menarche in girls with central precocious puberty. METHODS: The predicted adult height of 48 girls with central precocious puberty was calculated at diagnosis using the Bayley-Pinneau method based on average and advanced bone age tables and compared with the predicted adult height calculated using a mathematical model. In addition, the age at spontaneous menarche was predicted using the new formulae. After Gonadotropin-releasing hormone analog treatment, the predicted adult height was calculated using only the Bayley-Pinneau tables. RESULTS: The achieved adult height was within the target height range in all treated girls with central precocious puberty. At diagnosis, the predicted adult height using the Bayley-Pinneau tables was lower than that using the mathematical model. After the Gonadotropin-releasing hormone analog treatment, the predicted adult height using the Bayley-Pinneau method with the average bone age tables was the closest to the achieved adult height. Using the formulae, the predicted age at spontaneous menarche was 10.1±0.5 yr. The Gonadotropin-releasing hormone analog treatment significantly postponed this event until 11.9±0.7 yr in these "idiopathic" central precocious puberty girls, highlighting the beneficial effect of this treatment. CONCLUSION: Both initial adult height prediction methods are limited and must be used with caution. The prediction of the age at spontaneous menarche represents an innovative tool that can help in clinical decisions regarding pubertal suppression.

Early menarche and teenager pregnancy as risk factors for morbid obesity among reproductive-age women: A case-control study

OBJECTIVES: The aim of this study was to evaluate potential risk factors, including non-communicable diseases, for morbid obesity in women between 20 and 49 years of age. METHODS: We performed a case-control study with 110 morbidly obese women and 110 women with adequate weight who were matched by age and with a 1:1 case to control ratio. All women were between 20 to 49 years old and non-menopausal. Possible risk factors were evaluated through a self-report questionnaire assessing socio-demographic, obstetric and gynecological characteristics, presence of non-communicable diseases and habits. Multiple logistic regression was used to estimate the odds ratio with respective confidence intervals. RESULTS: Menarche under 12 years old, teenage pregnancy and lower educational level were shown to be risk factors for morbid obesity among women of reproductive age. Incidences of non-communicable diseases (diabetes, hypertension, dyslipidemia, liver disease, lung disease, thyroid dysfunction, and joint pain) were increased in women with morbid obesity. CONCLUSIONS: Early menarche, teenage pregnancy and low education level are risk factors for the occurrence of morbid obesity in women of reproductive age. Some non-communicable diseases were already more prevalent in women with morbid obesity even before 50 years of age.

Concordancia entre los índices de masa corporal nacional e internacional, como predictores de la composición corporal en adolescentes premenárquicas y menárquicas / Concordance between national and international bodymass index as a predictor of body composition in premenarcheal and menarcheal adolescents

El uso de referencias nacionales e internacionales para diagnosticar el estado nutricional es una discusión de larga data, debido a las discrepancias en los resultados. En este trabajo se contrastó la capacidad del índice de masa corporal (IMC) para predecir composición corporal, diagnosticada por área grasa (AG) y/o área muscular (AM), utilizando la referencia nacional (ENCDH) vs la internacional (OMS, 2007). Este estudio comparativo fue aplicado sobre una subpoblación de la base de datos de la Unidad de Bioantropología, Actividad Física y Salud, de 364 adolescentes femeninas, escolarizadas, entre 10 y 15 años, de distintas regiones venezolanas. Se calculó el coeficiente Kappa ponderado para medir la concordancia del IMC por ambas referencias, se determinó la precisión del IMC en cada caso, utilizando medidas de sensibilidad y especificidad. Se estimaron razones de verosimilitud diagnóstica para comparar el desempeño de ambos clasificadores de composición corporal. El índice Kappa ponderado mostró mayor concordancia en AG (0,64) que en AM (0,51). La presencia de la menarquia incrementó las concordancias: AG (0,63) y AM (0,59) con respecto a las pre-menárquicas: AG (0,46) y AM (0,35). Las razones de verosimilitud diagnóstica positivas y negativas resultaron consistentemente mayores que la unidad, tanto para la predicción de AM como AG, siendo siempre superiores en ENCDH que en OMS. Estos hallazgos muestran que en adolescentes pre-menárquicas la referencia ENCDH es más indicativa para el déficit y el exceso en área muscular, que la OMS, mientras que esta última es más indicativa del exceso en área grasa en adolescentes pre-menárquicas(AU)

Use of national and international references for the diagnosis of nutritional status is controversial. Concordance between national and international body mass index as predictors of body composition in 364 premenarcheal and menarcheal female adolescents (ages 10-15), classified according to occurrence of menarche, that were part of the database of the bioanthropology, physical activity and health unit, were evaluated. This study compares the capacity of body mass index (BMI) to predict body composition, diagnosed by upper arm fat area (UFA) and/ or upper arm muscle area (UMA), using national reference (ENCDH) vs International (WHO, 2007). The weighted Kappa coefficient was applied to evaluate the concordance between BMI by national and international references, as well as to assess the precision of BMI by means of sensibility and specificity. Additionally, diagnostic verisimilitude ratio was estimated to measure the efficiency of both references in the classification of body composition. The weighted Kappa showed greater concordance in UFA (0.64) versus UMA (0.51). The presence of menarche increased the concordances: UFA (0.63) and UMA (0.59) with respect to premenarcheal girls: UFA (0.46) and UMA (0.35). The positive and negative diagnostic likelihood ratios were consistently greater than one, for fat and muscle area, especially when using ENCDH reference. The findings suggest that prevalence of deficit or excess in UMA was more sensitive with the BMI_ENCDH than with the BMI_WHO, in premenarcheal girls. On the other hand, WHO was more sensitive to predict UFA excess in the same group(AU)

Desenvolvimento sexual e maturação puberal / Sexual and puberal development

Os fenômenos do desenvolvimento sexual e puberal são eventos progressivos e coordenados. Dependem de fatores cromossômicos - gênicos, gonadais e hormonais. Tais eventos nos indivíduos do sexo masculino e feminino, sendo sincrônicos, permitirão um conveniente desenvolvimento sexual e puberal. Analisar tais fenômenos é o propósito deste estudo.(AU)

The sexual and puberal modifications are coordinate and progressive during differents life phases. Many factors are involved like genic-chromosomic, gonadal and hormonal. Those events that occurred in males and females are synchronous and to create a perfect development. Our proposal is review those situations.(AU)

Puberty in a sample of Brazilian schoolgirls: timing and anthropometric characteristics

Objective The objective of this study was to determine the age at which puberty begins, age of menarche and anthropometric data of the participants at different stages of puberty. Subjects and methods This is a cross-sectional study in which we evaluated 665 girls, a sample representing the female schoolchildren population in Uberaba. Results We found that thelarche, pubarche, underarm hair and menarche were attained at the age of 9.8 ± 1.4, 10.2 ± 1.4, 10.5 ± 1.5 and 11.7 ± 1.3 years, respectively. The mean interval between thelarche and menarche (ITM) was 1.7 ± 1.3 years. The prevalence of overweight and obesity was 31.3% and 95% of the participants began at thelarche between the age of 7 and 12 years. Conclusion These values indicate a secular tendency to the decrease of the age of menarche and an earlier start of puberty. It is very important to understand these parameters to establish public policies aimed at plans to prevent these early events, especially regarding control of the prevalence of obesity. .

Age at menarche in schoolgirls with and without excess weight / Idade da menarca em escolares com e sem excesso de peso

OBJECTIVE: To evaluate the age at menarche of girls, with or without weight excess, attending private and public schools in a city in Southeastern Brazil. METHODS: This was a cross-sectional study comparing the age at menarche of 750 girls from private schools with 921 students from public schools, aged between 7 and 18 years. The menarche was reported by the status quo method and age at menarche was estimated by logarithmic transformation. The girls were grouped according to body mass index (BMI) cut-off points: (thin + normal) and (overweight + obesity). In order to ensure that they belonged to different strata, 328 parents of these schools answered a questionnaire to rate the student's socioeconomic level. RESULTS: Menarche was reported by 883 girls. Although they belonged to different classes (p < 0.001), there was no difference in the nutritional diagnosis (p = 0.104) between them. There was also no difference in age at menarche between the girls studying in private (12.1 years, 95% CI: 12.0-12.2) and public schools (12.2 years, 95% CI:12.1-12.3; p = 0.383). When evaluated by nutritional status, there was difference only in the age at menarche between girls from private schools with excess weight and without excess weight (11.6 and 12.3 years; p < 0.001). The girls with excess weight attending private schools also had earlier an menarche than those attending public schools (respectively, 11.6 and 12.1 years; p = 0.016). CONCLUSIONS: Although the students from private schools belonged to a higher socioeconomic status, there is currently no longer a large gap between them and girls from public schools regarding nutritional and socioeconomic factors that may influence the age at menarche. .

OBJETIVO: Avaliar a idade da menarca em meninas, com e sem excesso de peso, que frequentam escolas particulares e públicas de uma cidade do sudeste do Brasil. MÉTODOS: Estudo transversal que comparou a idade da menarca de 750 meninas de escolas particulares com 921 alunas de escolas públicas, com idades entre sete e 18 anos. A menarca foi relatada pelo método status quo e a idade da mesma estimada pelo logito. As meninas foram agrupadas pelos pontos de corte do IMC em (magreza + eutrofia) e (sobrepeso + obesidade). Com o intuito de certificar que elas pertenciam a classes diferentes, 328 pais responderam a um questionário para classificar o nível econômico dos alunos. RESULTADOS: A menarca foi referida por 883 meninas. Embora elas pertençam a classes econômicas distintas (p < 0,001), não houve diferença quanto ao diagnóstico nutricional (p = 0,104). Também não houve diferença na idade da menarca entre as que estudam em escolas particulares (12,1 anos; IC95%%: 12,0-12,2) e públicas (12,2 anos; IC95%%: 12,1-12,3); p = 0,383. Quando avaliadas pelo diagnóstico nutricional só houve diferença na idade da menarca das meninas com e sem excesso de peso de escolas particulares (11,6 e 12,3 anos; p < 0,001). As meninas com excesso de peso das escolas particulares também menstruaram mais cedo do que as das escolas públicas (respectivamente, 11,6 e 12,1 anos; p = 0,016). CONCLUSÕES: Embora as alunas das escolas particulares ainda pertençam a classes mais altas, atualmente, não existe mais um abismo nutricional e socioeconômico tão grande entre elas quanto a fatores que podem influenciar na idade da menarca. .

Avanços na etiologia, no diagnóstico e no tratamento da puberdade precoce central / Advances in the etiology, diagnosis and treatment of central precocious puberty

O início da puberdade caracteriza-se pelo aumento de amplitude e frequência dos pulsos do hormônio secretor de gonadotrofinas (GnRH) após um período de relativa supressão hormonal durante a infância. A reemergência da secreção pulsátil do GnRH resulta em aumento na secreção de gonadotrofinas, hormônio luteinizante (LH) e folículo estimulante (FSH), pela hipófise anterior e consequente ativação gonadal. A ativação prematura do eixo hipotálamo-hipófise-gonadal resulta em puberdade precoce dependente de gonadotrofinas, também conhecida como puberdade precoce central (PPC), e se caracteriza pelo desenvolvimento dos caracteres sexuais secundários antes dos 8 anos nas meninas e 9 anos nos meninos. O início do desenvolvimento puberal provém da interação complexa de fatores genéticos, nutricionais, ambientais e socioeconômicos. O diagnóstico clínico da PPC baseia-se em reconhecimento de desenvolvimento puberal progressivo, concentrações púberes de LH em condição basal e/ou após estímulo com GnRH e avanço de idade óssea. A ressonância magnética de encéfalo é útil no estabelecimento de diagnóstico diferencial entre as formas orgânica ou idiopática. Os análogos de GnRH de ação prolongada representam o tratamento de escolha da PPC. O componente genético da PPC foi recentemente fortalecido pela evidência de mutações no gene MKRN3, localizado no braço longo do cromossomo 15, em crianças com PPC familial. Nessa revisão, dados clínicos e terapêuticos da PPC serão amplamente discutidos, visando à atualização e à conduta criteriosa dessa condição clínica de grande relevância na endocrinologia pediátrica.

The onset of puberty is first detected as an increase in the amplitude and frequency of pulses of gonadotropin-releasing hormone (GnRH) after a quiescent period during childhood. The reemergence of pulsatile GnRH secretion leads to increases in the secretion of the gonadotropins, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) by the pituitary gland, and the consequent activation of gonadal function. Early activation of the hypothalamic–pituitary–gonadal axis results in gonadotropin-dependent precocious puberty, also known as central precocious puberty (CPP), which is clinically defined by the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Pubertal timing is influenced by complex interactions among genetic, nutritional, environmental, and socioeconomic factors. CPP is diagnosed on the basis of clinical signs of progressive pubertal development before the age of 8 years in girls and 9 years in boys, pubertal basal and/or GnRH-stimulated LH levels, and advanced bone age. Magnetic resonance imaging of the central nervous system is essential for establishing the CPP form as organic or idiopathic. Depot GnRH-analogues represent the first-line of therapy in CPP. Very recently, the genetic component of CPP was demonstrated by the evidence that the deficiency of the MKRN3 gene, located on long arm of chromosome 15, causes familial CPP in humans. In this current review, clinical and therapeutic aspects of the CPP will be discussed, contributing to adequate diagnosis and criterious approach of this relevant condition of pediatric endocrinology.

A menarca e seu impacto nas qualidades físicas de escolares / The menarche and its impact on schoolgirls' physical qualities / Impacto de la menarquía en las capacidades físicas de escolares

Objetivos Analisar a idade de ocorrência da menarca em escolares de Angra dos Reis/RJ e o comportamento das qualidades físicasem diferentes períodos da puberdade, utilizando a menarca como referência da maturação sexual. Métodos A amostra constou de 232 meninas com idades entre 10 e 16 anos divididas em quatro grupos de acordo com a maturação sexual. Após a entrega da anamnese referente à menarca foram marcados os dias dos testes motores para avaliar a qualidades físicas força explosiva de membros inferiores, velocidade de corrida, flexibilidade e consumo máximo de oxigênio absoluto e relativo. Utilizou-se a estatística descritiva para avaliar a idade da menarca; a ANOVA one way e a correlação de Pearson (p<0,05) foram utilizadas para analisar o comportamento das qualidades físicas de acordo com o período da menarca. Resultados A idade da menarca foi 12,23±1,2 anos e diferenças significativasentre os grupos foram encontradas nas qualidades físicas força explosiva de membros inferiores, velocidade de corrida e consumo máximo de oxigênio absoluto e relativo. Conclusões A ocorrência da idade da menarca foi condizente com a de estudos realizados no Brasil. Durante a puberdade a força explosiva de membros inferiores e a velocidade de corrida aumentam, o consumo máximo de oxigênio absoluto aumenta com tendência de queda dois anos após a menarca e oconsumo máximo relativo apresenta declínio durante a puberdade.(AU)

Objectives Ascertaining the age when the menarche occurs in school girls living in Angra dos Reis/RJ and the pattern of physical qualities in periods during puberty using the menarche as the benchmark for sexual maturation. Methods The sample consisted of 232 10-to16-year-old girls, divided into four groups according to sexual maturation. Following an interview during which the onset of the menarche was recalled, motor tests were scheduled for assessing physical qualities, lower limb power, running speed, flexibility and relative and absolute maximum oxygen consumption. Descriptive statistics were used for assessing the age of onset of the menarche; one-way ANOVA and Pearson's coefficient of correlation (p<0.05) were used for analyzing the physical qualities' pattern according to the onset of the menarche. Results The onset of the menarche was set at 12.23±1.2 years; significant differences were found regarding lower limb power, running speed, absolute and relative maximum oxygen consumption. Conclusions The occurrence of the onset of the menarche agreed with other studies carried out in Brazil. Lower limb power and running speed were seen to increase during puberty, absolute maximum oxygen consumption increased (tending to decline two years after the menarche) and relative oxygen consumption decreased.(AU)

Objetivo Analizar la edad de la menarquía, como una referencia de la maduración sexual de los escolares en Angra dos Reis/RJ, con respecto a las capacidades físicas en las diferentes etapas de la pubertad. Métodos La muestra se conformó con 232 niñas en edades comprendidas entre 10 y 16 años, divididos en cuatro grupos en función de la maduración sexual. Después de la entrevista, se aplicó un test de motricidad para evaluar las capacidades físicas, con base en la fuerza explosiva de miembros inferiores, la velocidad de carrera, la flexibilidad y el consumo máximo de oxígeno relativo y absoluto. Para evaluar la edad de la menarquía con respecto al comportamiento de las capacidades físicas, se utilizaron estadística descriptiva, ANOVA de una vía y la correlación de Pearson (p<0,05) Resultados La edad de la menarquía fue de 12,23±1,2 años y se encontraron diferencias significativas entre los grupos, con respecto a la fuerza explosiva de miembros inferiores, la velocidad de carrera y el consumo máximo de oxigeno relativo y absoluto. Conclusiones El papel de la edad de la menarquía estuvo de acuerdo con estudios realizados en Brasil. Durante la pubertad, la fuerza de miembros inferiores y la velocidad de carrera aumentan, el consumo máximo de oxígeno absoluto aumenta con tendencia a la baja dos años después de la menarquía y el consumo máximo relativo disminuye.(AU)

The monthly rhythm of incidence and age at menarche: thirty five years of research: The circa-vacation-study expectancy rhythm of incidence and age at menarche

The hypothesis that the vacation-study-expectancy scholar regime produces most of the monthly rhythm of the age at menarche (AaM) was tested. Studies on monthly menarche incidence (MI) refuted climatic factors as a main factor in this rhythm, and indicated that the main factor of this rhythm is the succession of expectancies of study (Stu-months) or vacation (Vac-months) months within a year. Thus the hypothesis of seasonal circa-annual rhythm should be modified to the circa-[vacation (fiesta)]-[study (non-fiesta)]-expectancies rhythm for the MI and age at menarche annual rhythms. In several countries Vac-months had higher MI than Stu-months. The high MI of Vac-months was followed by a large decrease when girls started their studies and a MI increase occurred as vacations approached. The hypothesis proposes that at the end of vacations and at the beginning of the study period the AaM should be lowest, and then the mean of AaM should increase because of the menarche delay of girls whose menarche was arrested by the initiation of school work. This pattern was found in four independent samples, from Chile, Colombia, USA and Brazil. The probability that this result be due to random fluctuation of means is extraordinarily low (P<10-8). I conclude that the influence of the expectancy of vacation and study periods on the monthly rhythm of the age at menarche is a real process that accounts for most of this rhythm.

Edad de menarquia y ascendencia indígena: Un estudio poblacional en Chile / Age at menarche and indigenous ancestry: A population study in Chile

Background: The age at menarche may influence decisively health and disease in women. It also indicates the beginning of the reproductive period and, as a consequence, the possibility of biological continuity for the human species. Genetic and environmental determinants define the age of menarche and can explain differences found among different populations. Aim: To determine the age at menarche among adolescents with different levels of indigenous descent (parental indigenous surnames), considering the effect of socioeconomic and demographic factors. Material and Methods: An observational study of historic cohorts of8.624 girls from the Arauca-nía Region (central-southern Chile) was carried out. Data were collected by health professionals using a previously validated questionnaire. Occurrence of menarche was estimated through survival analysis and compared between groups (according to indigenous parental surnames) adjusted for parents' income and educational level and provenance (rural/urban). Results: Estimated median age of menarche was 151 months (95% Cl: 150-151). In female with four indigenous surnames, menarche occurred two months later than girls without indigenous surnames and with two indigenous surnames (p < 0,001). In girls whose parents had lowest level of schooling, the difference increased to eight months later (p < 0,005). Conclusions: Age at menarche in the group with higher indigenous descent is later even if socio-economic conditions remain stable. Genetic factors might play an important role, however conditions of vulnerability can influence and further delay the onset of reproductive competency.

Socioeconomic status and age at menarche in indigenous and non-indigenous Chilean adolescents / Nivel socioeconómico y edad de la menarquia en adolescentes chilenas indígenas y no indígenas

The objective was to analyze the relationship between socioeconomic status and age at menarche among indigenous and non-indigenous girls in the Araucanía Region of Chile, controlling for nutritional status and mother's age at menarche. A total of 8,624 randomly selected girls from 168 schools were screened, resulting in the selection of 207 indigenous and 200 non-indigenous girls who had recently experienced menarche. Age at menarche was 149.6±10.7 months in the indigenous group and 146.6±10.8 months in the non-indigenous group. Among the non-indigenous, the analysis showed no significant association between age at menarche and socioeconomic status. In the indigenous group, age at menarche among girls with low socioeconomic status was 5.4 months later than among those with higher socioeconomic status. There were no differences in nutritional status according to socioeconomic level. Obesity was associated with earlier menarche. Menarche occurred earlier than in previous generations. An inverse relationship between socioeconomic status and age at menarche was seen in the indigenous group only; low socioeconomic status was associated with delayed menarche, regardless of nutritional status or mother's age at menarche.

El objetivo fue analizar la relación entre nivel socioeconómico y edad de menarquia en adolescentes indígenas y no indígenas de la Región de la Araucanía, Chile, controlando el efecto del estado nutricional, y la edad de menarquia de las madres. Se estudiaron 8.624 niñas de 168 escuelas elegidas aleatoriamente, seleccionando 207 indígenas y 200 no indígenas que habían tenido recientemente la menarquia. La edad de menarquia ocurrió a los 149,6±10,7 meses en indígenas y a los 146,6±10,8 meses en no indígenas. En el grupo no indígena, hubo una relación significativa entre edad de menarquia y nivel socioeconómico. En el grupo indígena, edad de menarquia del nivel socioeconómico bajo fue de 5,4 meses más tarde que el nivel socioeconómico más alto. No se observaron diferencias de estado nutricional por nivel socioeconómico. La obesidad adelantó la menarquia y la edad de menarquia ocurrió antes que la de sus madres. Existe una relación inversa entre nivel socioeconómico y edad de menarquia sólo en el grupo indígena; en los niveles socioeconómicos más bajos la edad de menarquia se retrasa independiente del estado nutricional y de la edad de menarquia de la madre.

Tendência secular da idade da menarca avaliada em relação ao índice de massa corporal / Secular trends in age at menarche in relation to body mass index

OBJETIVO: Avaliar a tendência secular da menarca de acordo com o índice de massa corporal (IMC). SUJEITOS E MÉTODOS: Seiscentos e oitenta e cinco meninas (7-18 anos) avaliadas em 2001 foram comparadas a 750 avaliadas em 2010. Elas foram agrupadas pelo Z-escore do IMC em: (magreza + eutrofia) e (sobrepeso + obesidade). A menarca foi relatada pelo status quo e a idade, estimada pelo logito. Foram utilizados os testes Qui-quadrado, Mann-Whitney e a Regressão logística, com significância de 5%. RESULTADOS: A menarca adiantou 3,24 meses entre 2001 e 2010. Houve aumento da obesidade e diminuição de eutróficas. O evento antecipou 1,44 mês no grupo magreza + eutrofia e 5,76 meses no sobrepeso + obesidade. Não houve interação entre os efeitos determinados pelo período avaliado e diagnóstico nutricional. CONCLUSÕES: Embora tanto o período quanto o IMC tenham influenciado a menarca, não se pode atribuir essa antecipação só à mudança do perfil nutricional da amostra. Outros fatores não testados podem estar contribuindo também para isso.

OBJECTIVE: To evaluate the secular trend of menarche according to body mass index (BMI). SUBJECTS AND METHODS: Six hundred and eighty five girls (7-18 years) assessed in 2001 were compared with 750 evaluated in 2010. They were grouped by BMI Z-score: (thin + normal) and (overweight + obese). Menarche was reported by status quo and age at menarche estimated by a logit model. We used the Qui-square test, Mann-Whitney test, and Logistic Regression, at a 5% significance level. RESULTS: Menarche advanced 3.24 months. There was an increase in obesity, and a decrease of the prevalence of normal girls. Menarche was anticipated by 1.44 month in the thin + normal group and by 5.76 months in the overweight + obese group. There was no interaction between the effects determined by the evaluated period and nutritional diagnosis. CONCLUSIONS: Although both the period and BMI influence the menarche, one cannot attribute this advance only to changes in the nutritional profile of the sample. Other factors that were not tested may also contribute to this finding.